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4tySix Music AI - Edge of the Storm (Official Music Video)
⏲ 2:39 👁 45K
7 Aum Arivu - Yellae Lama Video | Suriya, Shruti | Harris Jayaraj
⏲ 4 minutes 58 seconds 👁 18.2M
நலம் வாழ | Nalam Vazha | Marupadiyum | Tamil Superhit Video Song HD
⏲ 4 minutes 47 seconds 👁 7.4M
Unveiling hidden hearts - Red Media
⏲ 2:19:17 👁 20K
Balam | Ekaki Mon | একাকি মন | বালাম | TI Antor | Official Music Video
⏲ 5 minutes 22 seconds 👁 32.9M
Tumi amar New bangla album gan 2018 tipsbanglatv
⏲ 7 minutes 35 seconds 👁 127.4K
4tySix Music AI - Echoes of the Rebellion (Official Music Video)
⏲ 2:39 👁 15K
Bhalo Lage Swapnoke | Hero | Jeet | Koel Mallick | Shreya Ghoshal | Sonu Nigam | Jeet Gannguli
⏲ 5 minutes 36 seconds 👁 23.4M
I blackened my bones Leena Tasnim Samya ||
⏲ 3 minutes 12 seconds 👁 165
How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
மே 24 இன எழுச்சி அரசியல் மாநாட்டில்தேசிய தலைவர்பாடல்
⏲ 5 minutes 34 seconds 👁 2.3M
VTS 01 2
⏲ 24 minutes 31 seconds 👁 1.3M
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_4tysix-music-ai-edge-of-the-storm-official-music-video.webp "\")
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_124-nalam-vazha-124-marupadiyum-124-tamil-superhit-video-song-hd.webp "Bravo Musik")
_unveiling-hidden-hearts-red-media.webp "Unveiling hidden hearts")
_balam-124-ekaki-mon-124-124-124-ti-antor-124-official-music-video.webp "Sangeeta Music")
_tumi-amar-new-bangla-album-gan-2018-tipsbanglatv.webp "TIPS BANGLA TV")
_4tysix-music-ai-echoes-of-the-rebellion-official-music-video.webp "\")
_bhalo-lage-swapnoke-124-hero-124-jeet-124-koel-mallick-124-shreya-ghoshal-124-sonu-nigam-124-jeet-gannguli.webp "SurinderFilms")
_i-blackened-my-bones-leena-tasnim-samya-124124.webp "Bangla Gan")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_24.webp "நாம் தமிழர் கட்சி - Naam Thamizhar Katchi")
_vts-01-2.webp "Mamachi Valvai")
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